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3Use of Pharmacokinetics and Pharmacodynamics in Preclinical Studies to Guide Dosage Escalation Schemes in Phase I Studies of Anticancer Drugs, Integration of Pharmacokinetics, Pharmacodynamics, and Toxicokinetics in Rational Drug Development Molecular targets in the National Cancer Institute drug screen, Journal of Cancer Research and Clinical Oncology Phase I/pharmacokinetic trial of the novel thioxanthone SR233377 (WIN33377) on a 5-day schedule, Cancer Chemotherapy and Pharmacology