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8Clinical Studies with Epothilones, The Epothilones: An Outstanding Family of Anti-Tumor Agents N-Heterocyclic Carbene Complexes in Industrial Processes, N-Heterocyclic Carbenes in Transition Metal Catalysis and Organocatalysis Phase I dose escalation study of KOS-1584, a novel epothilone, in patients with advanced solid tumors, Cancer Chemotherapy and Pharmacology Impact, mechanisms, and novel chemotherapy strategies for overcoming resistance to anthracyclines and taxanes in metastatic breast cancer, Breast Cancer Research and Treatment New Therapeutic Options for Chemotherapy-Resistant Metastatic Breast Cancer, Drugs Discovery and Development of the Epothilones, Drugs in R & D