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4Plks as Novel Targets for Cancer Drug Design, Checkpoint Responses in Cancer Therapy In vivo antitumor activity of a novel sulfonamide, HMN-214, against human tumor xenografts in mice and the spectrum of cytotoxicity of its active metabolite, HMN-176, Investigational New Drugs Investigation of HMN-176 anticancer activity in human tumor specimens in vitro and the effects of HMN-176 on differential gene expression, Investigational New Drugs