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7Novel Agents in Multiple Myeloma, Advances in Biology and Therapy of Multiple Myeloma Fragment-Based Drug Discovery Using Rational Design, Sparking Signals Targeting Cyclin-Dependent Kinases with Small Molecule Inhibitors, Checkpoint Controls and Targets in Cancer Therapy Interactions of cyclin-dependent kinase inhibitors AT-7519, flavopiridol and SNS-032 with ABCB1, ABCG2 and ABCC1 transporters and their potential to overcome multidrug resistance in vitro, Cancer Chemotherapy and Pharmacology Transcriptional repression of DNA repair genes is a hallmark and a cause of cellular senescence, Cell Death & Disease mTOR caveats, Science-Business eXchange (S)-Lacosamide Binding to Collapsin Response Mediator Protein 2 (CRMP2) Regulates CaV2.2 Activity by Subverting Its Phosphorylation by Cdk5, Molecular Neurobiology